Charlie Bartlett's transition into a new high school isn't going as smoothly as he hoped; his unique personality clashes with the rigid expectations of the social hierarchy. Desperate for connection, Charlie comes up with an unorthodox plan to earn popularity by establishing himself as the school's de-facto therapist. He uses his quick wit and deep understanding of human psychology to provide both emotional support and, on occasion, medication, to the students who seek him out. Through this role, Charlie discovers that he has the power to affect positive change in his peers' lives, sparking an exploration of friendship, empathy, and self-acceptance amidst the turbulence of adolescence.
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